---
title: High Performance Single-Pass Tangential Flow Filtration Holder
description: The BPES high performance single-pass tangential flow filtration holder allows up to a 4x concentration of product with one single pump pass.
image: https://blog.cpsgrp.com/hubfs/CPSGrp_Feb2017/_Home/3%20blog%20images/BPES%20(FS%20Fitzy)/HP-SP-Tangential-Flow-Filtration-Holder.png
---

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# Exentec BioPharma Solutions

## High Performance Single-Pass Tangential Flow Filtration Holder

Posted by [BPES](https://blog.cpsgrp.com/bpes/author/bpes) on Mar 12, 2020 4:51:00 PM

### **Allows Up To 4x Concentration of Product with One Single Pump Pass **

The unique configuration of the Exentec BioPharma Solutions high performance single‐pass tangential flow filtration holder allows the retentate from the first bank of filter modules to be fed directly into the feed port of the 2nd bank of filter modules. This can be repeated from 2 up to 4x. This allows up to a 4X concentration of product with one single pump pass.

![HP-SP-Tangential-Flow-Filtration-Holder](https://blog.cpsgrp.com/hs-fs/hubfs/CPSGrp_Feb2017/_Home/3%20blog%20images/BPES%20(FS%20Fitzy)/HP-SP-Tangential-Flow-Filtration-Holder.png?width=1095&name=HP-SP-Tangential-Flow-Filtration-Holder.png)

Reducing the number of pump passes will provide higher product yield, and reduced product temperature rise from pumping. The permeate and retentate generated from this process will be collected in isolated streams at the outlet of the filter holder. Holder is directly compatible with Millipore Sigma & Pall UF Cassettes, Sartorius and others can be loaded with optional adapter plates.

[Download Our High Performance Single-Pass Tangential Flow Filtration Holder Brochure Here](https://www.bpesys.com/PDF/bpes-high-performance-sptff-flyer.pdf)

**Product Details:**

|   **Membrane & Holder** |   **Description** |
| --- | --- |
| TFF Device: | Ultra Filtration Cassette |
| Membrane Manufacture: | Sartorius / MilliporeSigma / PALL |
| Min/Max Filter Area: | .20m2 to 80m2 (Subject to Filter Membrane Manuf. & Model) |
| Holder Closure Mechanism: | Manual and Hydraulic |
| SIP / CIP Capable: | Yes |
| System Process Connections: | 1.5”(40mm) up to 4" TC Feed & Retentate / 1” (25mm) up to 2" TC Permeate/Drain ( Dependent on filtration area required) |
| Product Contact Material: | 316L SS, AL6XN or Hastrelloy |
| Elastomers: | USP Class VI EPDM / Teflon/ Silicone |
| ID Finish (wetted surfaces): | 15ra u‐in W/Electro Polish |
| OD Finish (non-wetted surfaces): | 35ra u‐in Mechanical Finish |
| Passivation (wetted surface): | Yes |
| MAWP: | 6.8 Bar (Subject to Filter Membrane Manuf. & Model) |
| Feed Flow Range: | Dependent on filtration area required |
| Documentation: | 1 Hard and Soft Copy Turn‐Over‐Package (TOP) Provided |

**BioPharm Engineered Systems** provides specialized engineering, design, manufacturing and support services for a complete range of custom process separation and fluid handling system solutions. Our core competencies include:

- Process Equipment and Modularization
- Upstream Processing Systems
- Downstream Processing Systems
- Process Support Systems/Infrastructure
- Custom Processing Systems
- Batching and Blending Systems
- Single Use/Disposable Support Systems
- And more...

[For more information about our Bioprocessing Equipment offerings, download our capabilities guide.](https://info.cpsgrp.com/life-science-bioprocessing-equipment)

OR

[Visit our Bioprocess Engineering Solutions page.](https://www.exentec.net/Products/Biopharma-Solutions)

Topics: [bioprocessing equipment](https://blog.cpsgrp.com/bpes/topic/bioprocessing-equipment), [tangential flow filtration](https://blog.cpsgrp.com/bpes/topic/tangential-flow-filtration)

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- [bioprocessing equipment (8)](https://blog.cpsgrp.com/bpes/topic/bioprocessing-equipment)
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